Patterns and Relevance of Langerhans Islet Invasion in Pancreatic Cancer

Background: Pancreatic cancer‐associated diabetes mellitus (PC‐DM) is present in most patients with pancreatic cancer, but its pathogenesis remains poorly understood. Therefore, we aimed to characterize tumor infiltration Langerhans islets cancer and determine clinical relevance. Methods: islet invasion was systematically analyzed 68 ductal adenocarcinoma (PDAC) using histopathological examination 3D vitro migration assays were performed assess chemoattraction of cells cells. Results: all patients. We found four different patterns invasion: (Type I) peri‐insular directly touching the boundary, not penetrating islet; II) endo‐insular inside round III) distorted structure complete loss morphology; IV) adjacent solitary encountered did exhibit any vitro. Further, there no correlation novel Islet Invasion Severity Score (IISS), which includes occurrence mellitus. However, Type IV related worsened overall survival our cohort. Conclusions: analyzed, for first time, human cancer. Four main identified. Diabetes invasion. more research on this prevailing feature needed better understand underlying principles.